Clinicopathological Significance of p53, Hypoxia-inducible Factor 1 alpha, and Vascular Endothelial Growth Factor Expression in Colorectal Cancer

作者：Kwon Hyuk Chan; Kim Sung Hyun; Oh Sung Yong; Lee Suee; Kwon Kyung A; Choi Hong Jo; Park Ki Jae; Kim Hyo Jin; Roh Mee Sook^*

来源：Anticancer Research, 2010, 30(10): 4163-4168.

• p53
• hypoxia-inducible factor 1 alpha
• vascular endothelial growth factor
• colorectal carcinoma

Background: The principal objective of this study was to evaluate the prognostic significances of p53, hypoxia inducible factor-1 alpha (HIF-1 alpha), and vascular endothelial growth factor (VEGF) expression in colorectal cancer. Materials and Methods: The tumor tissues of 311 patients with colorectal carcinoma that had undergone potentially curative resections were immunohistochemically assessed using monoclonal antibodies against p53, HIF-1 alpha, and VEGF. Results: Positivity rates of p53, HIF-1 alpha, and VEGF were 42.4%, 63.0%, and 56.6%, respectively. HIF-1 alpha expression in tumor tissues was determined to be correlated significantly with the expression of VEGF (p=0.040), and depth of invasion (p=0.019). Multivariate analysis demonstrated that HIF-1 alpha was independently associated with poor overall survival (p=0.002). Conclusion: HIF-1 alpha expression is associated with VEGF expression and angiogenesis in colorectal carcinoma. Additionally, the expression of HIF-1 alpha in tumor tissue is associated with angiogenesis and poor overall survival in patients with colorectal cancer.

• 出版日期2010-10