Non-steroidal anti-inflammatory drugs: use and co-treatment with potentially interacting medications in the elderly

作者：Vandraas Kathrine F; Spigset Olav; Mahic Milada; Slordal Lars^*

来源：European Journal of Clinical Pharmacology, 2010, 66(8): 823-829.

DOI：10.1007/s00228-010-0825-2

• NSAIDs
• Elderly
• Adverse drug reactions
• Co-prescription
• Drug interactions

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the elderly. NSAIDs may cause a series of adverse drug reactions, of which gastrointestinal, renovascular/cardiovascular and bleeding complications are of particular concern. Concomitant use of several other drugs may further increase the risk of these adverse effects.
To examine the extent of chronic use of NSAIDs and co-prescription of drugs which may seriously interact with NSAIDs in elderly subjects, by using data from the Norwegian Prescription Database.
A total of 7.3% of all individuals (71,681/984,457) over 60 years of age filled at least one prescription for reimbursed NSAIDs during the 1-year study period (2006). Co-prescription of medications which may interact with NSAIDs was prevalent for drugs used for hypertension and/or heart failure (59.5%), antithrombotic drugs (35.1%), systemic glucocorticoids (12.9%) and SSRI antidepressants (8.3%). As many as 4.8 and 3.8% of NSAID users were co-prescribed warfarin or oral methotrexate respectively.
The frequent co-prescription of medications which may cause detrimental interactions in elderly chronic NSAID users adds to safety concerns regarding this widely prescribed class of drugs.

• 出版日期2010-8