Preparation, in vitro characterization, pharmacokinetic, and pharmacodynamic evaluation of chitosan-based plumbagin microspheres in mice bearing B16F1 melanoma

作者：Rayabandla Sunil Kumar Mandala; Aithal Kiran; Anandam Aravind; Shavi Gopal; Nayanabhirama Udupa; Arumugam Karthik; Musmade Prashant; Bhat Krishnamoorthy; Sadashiva Satish Rao Bola^*

来源：Drug Delivery, 2010, 17(3): 103-113.

DOI：10.3109/10717540903548447

• Plumbagin
• chitosan
• microspheres
• pharmacokinetics
• pharmacodynamics

The present study was aimed to evaluate the anti-tumor efficacy and systemic toxicity of chitosan-based plumbagin microspheres in comparison to free plumbagin. The optimized formulation had a mean particle size of 106.35 mu m with an encapsulation efficiency of 80.12%. Pharmacokinetic studies showed a 22.2-fold increase in elimination half-life (t(1/2)) of plumbagin from chitosan microspheres as compared to free plumbagin. Administration of plumbagin microspheres resulted in a significant tumor growth inhibition and reduced systemic toxicity. These results suggest that chitosan-based microspheres could be a promising strategy for the systemic delivery of anti-cancer agents like plumbagin.</.

• 出版日期2010-4