Secondary Phosphine Oxide Preligands for Palladium-Catalyzed C-H (Hetero)Arylations: Efficient Access to Pybox Ligands

作者：Ghorai Debasish; Mueller Valentin; Keil Helena; Stalke Dietmar; Zanoni Giuseppe; Tkachenko Boryslav A; Schreiner Peter R; Ackermanna Lutz^*

来源：Advanced Synthesis & Catalysis, 2017, 359(18): 3137-3141.

DOI：10.1002/adsc.201700663

• C-H activation
• heteroarylation
• oxazolines
• palladium
• pybox ligands
• secondary phosphine oxides

C-H arylations of oxazolines were accomplished with a well-defined palladium catalyst derived from a secondary bisdiamantyl phosphine oxide. The single-component secondary phosphine oxide (SPO)-palladium complex enabled C-H activations with aryl bromides and challenging aryl chlorides in the absence of directing groups, setting the stage for the step-economical synthesis of pybox ligands under racemization-free reaction conditions.

• 出版日期2017-9-18