The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy

作者：Wilkinson Simon^*; Croft Daniel R; O'Prey Jim; Meedendorp Arenda; O'Prey Margaret; Dufes Christine; Ryan Kevin M

来源：Autophagy, 2011, 7(11): 1295-1301.

DOI：10.4161/auto.7.11.16646

• PITSLRE
• CDK11
• cyclin-dependent kinase
• autophagy
• human
• Drosophila

(Macro)autophagy is a membrane-trafficking process that serves to sequester cellular constituents in organelles termed autophagosomes, which target their degradation in the lysosome. Autophagy operates at basal levels in all cells where serves as a homeostatic mechanism to maintain cellular integrity. The levels and cargoes of autophagy calli however, change in response to a variety of stimuli, and perturbations autophagy are known to be involved in the etiology of various human diseases. Autophagy must therefore be tightly controlled We report here that the Drosophila cyclin-dependent kinase PITSLRE is a modulator of autophagy. Loss of the human PITSLRE ortholog CDK11, initially appears to induce autophagy, but at later time points CDK11 critically required for autophagic flux and cargo digestion, Since PITSLRE/CDK11 regulates autophagy in both Drosophila and human cells, this kinase represents a novel phylogenetically conserved component of the autophagy machinery.

• 出版日期2011-11