Determinants of varicella breakthrough Results of a 2012 case control study

作者：Tafuri Silvio^*; Guerra Rocco; Cappelli Maria Giovanna; Martinelli Domenico; Prato Rosa; Germinario Cinzia

来源：Human Vaccines & Immunotherapeutics, 2014, 10(3): 667-670.

DOI：10.4161/hv.27382

• vaccine failure
• breakthrough
• varicella
• UMV
• varicella vaccine schedule

This study aims to evaluate the determinants of breakthrough infection after one dose of varicella vaccine.
We designed a retrospective case-control study. Breakthrough cases were children, aged 1-15, who presented varicella symptoms >= 42 days after the first dose of varicella vaccine (breakthrough). Controls were children, aged 1-15 years, who attended the same class (in a school or in a kindergarten) than the cases in the year of the breakthrough onset; they received a dose of varicella vaccine >= 42 days before the case rash onset and they did not develop varicella symptoms.
We enrolled 45 cases and 135 controls. 40% of cases (n = 18; 95% CI = 25.4-54.6) presented at least one risk factor; this proportion was 39.2% (95% CI = 30.9-47.6) among the controls (chi-square = 0.0078; P = 0.93). Time between vaccination and virus exposure was longer among cases. Logistic regression showed that breakthrough disease was associated with duration of time from vaccination.

• 出版日期2014-3