Antioxidant and in vitro anticancer activities of phenolics isolated from sugar beet molasses

作者：Chen Mingshun; Meng Hecheng; Zhao Yi; Chen Fuquan; Yu Shujuan^*

来源：BMC Complementary and Alternative Medicine, 2015, 15(1): 313.

DOI：10.1186/s12906-015-0847-5

• Sugar beet molasses
• Phenolic compounds
• Antioxidant activities
• Antitumor activities

Background: In the present study, the phenolic compounds were prepared using ultrasonic-aid extraction from sugar beet molasses (SBM).
Methods: Gallic acid (GA), cyanidin-3-O-glucoside chloride (CGC) and epicatechin (EP) were produced after column chromatography from the extraction, and further detected using NMR, QTOF-MS and ESI-MS/MS.
Results: The three compounds exhibited strong antioxidant activities including DPPH radical scavenging activities, ABTS radical scavenging activities and ORAC values. GA showed the strongest antioxidant activity. Antitumor activities significantly increased in a dose-dependent manner. In particular, the CGC had growth inhibitory activities of 94.86, 87.27 and 67.13 % against the human colon (CACO-2), hepatocellular (HepG2) and breast (MCF-7) carcinoma cell lines, respectively, at the highest concentration of 400 mu g/mL of the extracts. These results suggest that the three compounds are key chemical compositions valuable for preparing functional foods in the food industry.
Conclusions: The results suggested that SBM is a natural source of antioxidant and antitumor agents for preparing functional foods.

• 出版日期2015-9-7
• 单位华南理工大学