A green route to beta-amino alcohols via the uncatalyzed aminolysis of 1,2-epoxides by alkyl- and arylamines

作者:Bonollo Simona*; Fringuelli Francesco; Pizzo Ferdinando; Vaccaro Luigi
来源:Green Chemistry, 2006, 8(11): 960-964.
DOI:10.1039/b607620c

摘要

Under mildly basic and pH-controlled aqueous conditions the aminolysis of 1,2-epoxides 1a-g by alkyl- and arylamines 2a-k is generally highly regioselective giving the corresponding beta-amino alcohols in satisfactory to excellent yields.

  • 出版日期2006