Detection of a new species of torque teno mini virus from the gingival epithelium of patients with periodontitis

作者：Zhang, Yu; Li, Fei; Chen, Xi; Shan, Tong-Ling^*; Deng, Xu-Tao; Delwart, Eric; Feng, Xi-Ping^*

来源：Virus Genes, 2017, 53(6): 823-830.

DOI：10.1007/s11262-017-1505-4

• Anellovirus
• TTMV
• Periodontitis
• Viral metagenomics

We describe a novel species of torque teno mini virus called TTMV-204, which was isolated from the gingival epithelium of patients with periodontitis and characterized using viral metagenomics. The sequence of the full genome is 2824 nt in length. Phylogenetic analysis and genetic analyses show classic Betatorquevirus species organization with less than 40% amino acid similarity in ORF1. The prevalence of TTMV-204 in the periodontitis patient population was 18.75% (15/80), which was higher than in periodontally healthy individuals (10.00%, 10/80). However, the difference of the TTMV-204 prevalence between two groups was not statistically significant (p = 0.115). Further investigation is required to determine whether this new virus is associated with inflammation.

• 出版日期2017-12
• 单位上海交通大学; 中国农业科学院上海兽医研究所; 上海市口腔病防治院