N-stearoyltyrosine dipotassium ameliorates high-fat diet-induced obesity in C57BL/6 mice

作者：Tang, Shuang-Qi; Yin, Sha; Liu, Sha; Le, Ke-Jia; Yang, Ruo-Lin; Liu, Jian-Hua; Wang, Xiao-Lin; Zheng, Zhao-Xi; Zheng, Lin; Lin, Qiang; Lu, Yang^*

来源：European Journal of Pharmaceutical Sciences, 2015, 74: 18-26.

DOI：10.1016/j.ejps.2015.03.022

• N-stearoyltyrosine dipotassium
• Diet-induced obesity
• Anti-inflammation
• beta-oxidation

N-stearoyltyrosine dipotassium (NST-2K) as a neuroprotective candidate is currently in preclinical studies in China. This study investigated the anti-obese effect of NST-2K in high-fat diet-induced obese (DIO) mice. The DIO mice were induced from male C57BL/6 mice by feeding high-fat diet for 11-weeks and treated orally with NST-2K for other 4 weeks. The treatments of DIO mice with NST-2K at 60 or 100 mg/kg/day suppressed the body weight gain, decreased both visceral fat weight and adipocyte size without influence on food intake. To evaluate the effect of NST-2K on lipid metabolism, lipid parameters and several key molecules in the plasma, liver, duodenum mucosa and adipose tissue were analyzed. NST-2K ameliorated the low-grade inflammation in liver, inhibited pancreatic lipase activity in duodenum mucosa, activated beta-oxidation system and reduced lipogenesis, thus suppressed lipid accumulation in the liver, reduced adipocyte size and improved lipid and carbohydrate metabolism. Overall, without influence on food intake, NST-2K ameliorated high-fat diet-induced obesity via suppressing liver inflammation, inhibiting dietary fat absorption, promoting lipolysis and reducing lipogenesis.

• 出版日期2015-7-10
• 单位上海交通大学