Nanoparticle-mediated cryosurgery for tumor therapy

作者：Hou, Yi; Sun, Ziqiao; Rao, Wei^*; Liu, Jing

来源：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 493-506, 2018-02.

DOI：10.1016/j.nano.2017.11.018

• Nano-cryosurgery
• Nanoparticle
• Ice crystal growth
• Thermal conductivity
• Minimally invasive

Cryosurgery is an energy-based surgical technique. It is minimally invasive and has fewer side effects than surgical resection. However, its insufficient freezing to target tumor and unavoidable injury to healthy tissue have restricted its success. Nano-cryosurgery is the combination of cryogenic biomedicine and nanotechnology. Its principle is to introduce a nanoparticle solution into target tissues to maximize heat transfer, lower the end temperature, increase ice ball formation, and prevent healthy tissues from being frozen. This review covers common nanoplatforms for nano-cryosurgery. The characteristics, advantages, potential challenges, future prospects of applying nano-cryosurgery are discussed in detail.

• 出版日期2018-2
• 单位中国科学院理化技术研究所; 北京建筑大学; 中国科学院大学; 清华大学