Structural and Functional Insights into the Cryoprotection of Membranes by the Intrinsically Disordered Dehydrins

作者:Clarke Matthew W; Boddington Kelly F; Warnica Josephine M; Atkinson John; McKenna Sarah; Madge Jeffrey; Barker Christine H; Graether Steffen P*
来源:JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290(45): 26900-26913.
DOI:10.1074/jbc.M115.678219

摘要

Background: Genetic evidence supports a protective role for plant dehydrins against drought and cold. Results: Dehydrins prevent membrane fusion and lower the transition temperature without altering membrane accessibility and fluidity. Conclusion: The lysine-rich segments are important for protecting membranes from freeze-thaw damage. Significance: An amphipathic helix with positively charged residues flanking the hydrophobic face may be a common motif for disordered stress proteins.

  • 出版日期2015-11-6