Morphology Change from Nanotube to Vesicle and Monolayer/Bilayer Alteration by Amphiphilic Block Polypeptides Having Aromatic Groups at C Terminal

作者：Kim Cheol Joo; Kurauchi Saki; Uebayashi Tsuguaki; Fujisaki Ai; Kimura Shunsaku^*

来源：Bulletin of the Chemical Society of Japan, 2017, 90(5): 568-573.

DOI：10.1246/bcsj.20170044

Various amphiphilic block polypeptides having aromatic groups at the C terminal of a Leu-based hydrophobic helical block, poly(sarcosine)-b-(L-Leu-Aib)(6)-ethylcarbazole, poly(sarcosine)-b-(D-Leu-Aib)(6)-naphthalimide, and poly(sarcosine)-b-(D-Leu-Aib)(6)-porphyrin, were synthesized and self-assembled in water. Molecular assemblies of distorted sheet, saddle-like sheet, and micelle were identified, which were different from the curved sheet of poly(sarcosine)-b-(L-Leu-Aib)(6) without any aromatic groups, indicating that the attachment of the aromatic groups to the C terminal significantly influenced the morphology. Upon heating at 90 degrees C, vesicles were generated with the three amphiphilic polypeptides with aromatic groups as opposed to the nanotubes of poly(sarcosine)-b-(L-Leu-Aib)(6). The precise observations of these vesicles by AFM revealed formation of monolayer for poly(sarcosine)-b-(L-Leu-Aib)(6)-ethylcarbazole and bilayers for poly(sarcosine)-b-(D-Leu-Aib)(6)-naphthalimide and poly(sarcosine)-b-(D-Leu-Aib)(6)-porphyrin. Attachment of aromatic groups at the C terminal therefore influences morphology and monolayer/bilayer alteration in accordance with the type of aromatic groups.

• 出版日期2017-5