A comparative study to screen dementia and APOE genotypes in an ageing East African population

作者：Chen Chien Hsiun; Mizuno Toshiki; Elston Robert; Kariuki Monica M; Hall Kathleen; Unverzagt Fred; Hendrie Hugh; Gatere Samuel; Kioy Paul; Patel Nilesh B; Friedland Robert P; Kalaria Raj N^*

来源：Neurobiology of Aging, 2010, 31(5): 732-740.

DOI：10.1016/j.neurobiolaging.2008.06.014

• Africa
• Alzheimer's disease
• Apolipoprotein E
• Cognitive impairment
• Dementia
• Kenya
• Neuropsychology

Previous studies have established cross-cultural methods to screen for ageing-related dementia and susceptibility genes, in particular Alzheimer's disease (AD) among the Canadian Cree, African Americans and Yoruba in Nigeria. We determined whether the Community Screening Interview for Dementia (CSID), translated into Kikuyu, a major language of Kenya, could be used to evaluate dementia of the Alzheimer type. Using two sets of coefficients of cognitive and informant scores, two discriminant DF) scores were calculated for each of 100 elderly (>65 years) Nyeri Kenyans. When the cut-off points were selected for 100% sensitivities, the specificities of the DF scores were remarkably similar (93.75%) in the Kenyan sample. We propose the adapted CSID can be utilised to detect dementia among East Africans. We also show that apolipoprotein E epsilon 4 allele frequencies were high (similar to 30%) and not different between normal subjects and those with probable AD. There was no evidence to suggest years of education or vascular factors were associated with dementia status.

• 出版日期2010-5