Alkoxy Tetrazine Substitution at a Boron Center: A Strategy for Synthesizing Highly Fluorogenic Hydrophilic Probes

作者：Wu, Min; Wu, Xiaoai; Wang, Yayue; Gu, Lei; You, Jiao; Wu, Haoxing; Feng, Ping^*

来源：ChemBioChem, 2018, 19(6): 530-534.

DOI：10.1002/cbic.201700556

• bioorthogonal chemistry
• dyes
• pigments
• fluorescent probes
• imaging agents
• tetrazines

Strongly fluorogenic boron dipyrromethene (BODIPY)-tetrazine probes have been obtained by introducing an alkoxy tetrazine fragment at the boron center. The fluorescence signal from these probes strongly increases by up to 225-fold after reaction with bioorthogonal coupling partners, and the hydrophilicity of probes is improved, such that they are suitable for live-cell imaging.

• 出版日期2018-3-16
• 单位四川大学