科研之友
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摘要
Objective: Diabetes mellitus is a common metabolic disorder characterized by hyperglycemia. Cytokines induce signal transduction and secondary messenger pathways after binding their specific ligands. In this way, these proteins control and also modulate activity of the target cells. Tumor necrosis factor plays an important role in diabetes and is a member of the family of cytokines. In this study, we aimed to investigate the effect of A252G (TNF-beta NcoI, rs909253) polymorphism in the tumor necrosis factor beta gene on the Type I Diabetes Mellitus in the Turkish population. %26lt;br%26gt;Materials and Method: Distribution of A252G polymorphism was determined in 96 patients with Type I diabetes and 101 healty individuals by PCR-RFLP. %26lt;br%26gt;Results: When obtained data was evaluated, the A allele of A252G polymorphism were observed more frequently than G allele in patients and controls. Moreover, G alleles were observed more frequently among patients than in controls. This high frequency of G allele found in patients demonstrates a 1.6 fold increased risk of susceptibility to type I diabetes in Turkish population (P=0.032). However, there was no significant difference between patients and controls in terms of the distribution of genotypes (P=0.132). %26lt;br%26gt;Conclusion: As a result, although presence of a G allele demonstrated an increased risk of susceptibilty to type I diabetes, TNF-beta A252G polymorphism%26apos;s genotype distrubution was not associated with type I diabetes in Turkish population. Polymorphisms involved in the development of Type I Diabetes Mellitus results in better understanding of the development and the progression of disease.
- 出版日期2012
