A spatiotemporal atlas of MR intensity, tissue probability and shape of the fetal brain with application to segmentation

作者：Habas Piotr A^*; Kim Kio; Corbett Detig James M; Rousseau Francois; Glenn Orit A; Barkovich A James; Studholme Colin

来源：NeuroImage, 2010, 53(2): 460-470.

DOI：10.1016/j.neuroimage.2010.06.054

• Structural MRI
• Fetal imaging
• Atlas building
• Tissue segmentation

Modeling and analysis of MR Images of the developing human brain is a challenge due to rapid changes in brain morphology and morphometry. We present an approach to the construction of a spatiotemporal atlas of the fetal brain with temporal models of MR intensity, tissue probability and shape changes This spatiotemporal model is created from a set of reconstructed MR images of fetal subjects with different gestational ages Groupwise registration of manual segmentations and voxelwise nonlinear modeling allow us to capture the appearance, disappearance and spatial variation of brain structures over time Applying this model to atlas-based segmentation, we generate age-specific MR templates and tissue probability maps and use them to initialize automatic tissue delineation in new MR images The choice of model parameters and the final performance are evaluated using clinical MR scans of young fetuses with gestational ages ranging from 20 57 to 24 71 weeks. Experimental results indicate that quadratic

• 出版日期2010-11-1