An amphiphilic fluorescent probe for the visualization of histamine in living cells

作者：Seto Daisuke; Soh Nobuaki; Nakano Koji; Imato Toshihiko^*

来源：Bioorganic & Medicinal Chemistry Letters, 2010, 20(22): 6708-6711.

DOI：10.1016/j.bmcl.2010.09.003

• Fluorescence imaging
• Histamine
• Ligand exchange
• Nile Red
• Sensor molecule

A novel fluorescent probe composed of two moieties, Nile Red and an iminodiacetic acid-Ni(2+) complex, for the detection of histamine in living cells is described. The probe was successfully applied to visualizing histamine in RAW264 cells, representing the first demonstration of the imaging of histamine itself in living cells.

• 出版日期2010-11-15