A New Dibenz[b,e]oxepine Derivative, 1-Hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione, from a Marine-Derived Fungus, Beauveria bassiana TPU942

作者：Yamazaki Hiroyuki; Rotinsulu Henki; Kaneko Tsuyoshi; Murakami Kazuki; Fujiwara Hiromu; Ukai Kazuyo; Namikoshi Michio^*

来源：Marine Drugs, 2012, 10(12): 2691-2697.

DOI：10.3390/md10122691

• dibenzooxepine derivative
• 1-hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione
• marine-derived fungus
• fungal metabolites

1-Hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione (1) was obtained from the culture broth of a marine-derived fungus, Beauveria bassiana TPU942, isolated from a marine sponge collected at Iriomote Island in Okinawa, together with two known compounds, chrysazin (2) and globosuxanthone A (3). The structure of 1 was elucidated on the basis of its spectroscopic data (HREIMS, 1D and 2D NMR experiments including H-1-H-1 COSY, HMQC and HMBC spectra). Dibenz[b,e]oxepines are rare in nature, and only six natural products have been reported. Therefore, compound 1 is the seventh natural product in this class. Compounds 2 and 3 showed an antifungal activity against Candida albicans, and 3 inhibited the cell growth against two human cancer cell lines, HCT-15 (colon) and Jurkat (T-cell lymphoma). Compound 1 did not show an apparent activity in the same bioassays.

• 出版日期2012-12