Phenylalanine Increases Membrane Permeability

作者:Perkins Russell; Vaida Veronica*
来源:Journal of the American Chemical Society, 2017, 139(41): 14388-14391.
DOI:10.1021/jacs.7b09219

摘要

Biological membranes are a crucial aspect of living systems, controlling the organization and distribution of different chemical components. Control of membrane permeability is especially important for processes such as electron transport in metabolism and signal propagation in nerve cells. In this work, we show that the amino acid phenylalanine produces increased membrane permeability, which is likely responsible for some of the deleterious symptoms associated with high biological phenylalanine concentrations that occur with the genetic disorder phenylketonuria.

  • 出版日期2017-10-18