Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1

作者：Hidaka Masafumi; Kosaka Keita; Tsushima Saori; Uchida Chiyoko; Takahashi Katsuhiko; Takahashi Noriko; Tsubuki Masayoshi; Hara Yukihiko; Uchida Takafumi^*

来源：Biochemical and Biophysical Research Communications, 2018, 499(3): 681-687.

DOI：10.1016/j.bbrc.2018.03.212

• Food polyphenols
• EGCG
• Caffeic acid
• Tannic acid
• Prolyl isomerase
• Pin1

We searched for inhibitors against prolyl isomerase Pin1 in order to develop functional foods to prevent and cure various Pin1 related diseases such as cancer, diabetes, cardiovascular disease, Alzheimers's disease, and so on. We created a polyphenol library consisting of ingredients in healthy foods and beverages, since polyphenols like epigallocatechin gallate (EGCG) in green tea and 974B in brown algae had been identified as its Pin1 inhibitors. Several polyphenols such as EGCG derivatives, caffeic acid derivatives and tannic acid inhibited Pin1 activity. These results provide a first step in development of the functional foods and beverage targeting Pin1 and its related diseases.

• 出版日期2018-5-15
• 单位河北医科大学