Antiviral therapy of two patients with chromosomally-integrated human herpesvirus-6A presenting with cognitive dysfunction

作者：Montoya Jose G; Neely Michael N; Gupta Sudhir; Lunn Mitchell R; Loomis Kristin S; Pritchett Joshua C; Polsky Bruce; Medveczky Peter G^*

来源：Journal of Clinical Virology, 2012, 55(1): 40-45.

DOI：10.1016/j.jcv.2012.05.016

• Human herpesvirus 6
• HHV-6
• Chromosomally integrated HHV-6
• CIHHV-6
• Inherited HHV-6

Background: Human herpesvirus 6 (HHV-6) is a neurotropic virus implicated in central nervous system (CNS) dysfunction, multiple sclerosis, seizures and encephalitis. Inherited or %26quot;chromosomally integrated%26quot; HHV-6 (CIHHV-6) is a condition characterized by high DNA loads and germ line transmission of HHV-6 genomes, which are integrated into the telomere. %26lt;br%26gt;Objectives: We previously reported that integrated HHV-6 can be reactivated by trichostatin A in vitro. Therefore, we hypothesized that a broad array of neurological symptoms of CIHHV-6 patients may respond to antiviral drug treatment. %26lt;br%26gt;Study design: The patients have been treated with antiviral drugs and monitored for viral load, late mRNA, and clinical improvement. %26lt;br%26gt;Results: Antiviral therapy of two CIHHV patients resulted in successful clinical resolution. However, both patients relapsed on multiple occasions within 4-6 months of cessation of antiviral therapy. %26lt;br%26gt;Conclusions: Successful antiviral drug treatment suggests that clinical symptoms of these patients were due to symptomatic reactivation of CIHHV-6. Alternatively, some CIHHV-6 patients may have a reduced resistance to community-acquired HHV-6 strains due to tolerance leading to persistent infections.

• 出版日期2012-9