No evidence of DISC1-associated morphological changes in the hippocampus, anterior cingulate cortex, or striatum in major depressive disorder cases and healthy controls

作者：Stacey David^*; Redlich Ronny; Opel Nils; Grotegerd Dominik; Arolt Volker; Kugel Harald; Heindel Walter; Baune Bernhard T; Dannlowski Udo

来源：Journal of Affective Disorders, 2014, 166: 103-107.

DOI：10.1016/j.jad.2014.05.001

• DISC1
• Major depressive disorder
• Imaging genetics
• Hippocampus

Background: DISCI imaging genetics studies in healthy controls, schizophrenia, and bipolar disorder cases have revealed morphological changes in brain regions involved in the pathophysiology of psychiatric disease including the hippocampus, anterior cingulate cortex (ACC), and the striatum. However, many of these studies have yielded discordant findings so there is a need for replication. Furthermore, despite evidence from human genetic studies and animal models implicating DISCI in major depressive disorder (MDD), a DISCI imaging genetics study in MDD cases has yet to be published. Thus, using neuroimaging data from MDD cases and a large sample of healthy controls we aimed to identify morphological changes representing neurobiological mechanisms underlying the association between DISCI and MDD. %26lt;br%26gt;Methods: We utilized structural magnetic resonance imaging (sMRl) data from 512 healthy controls and 171 current MDD (SOD interview) cases, each with genotype data for non-synonymous DISCI SNPs rs3738401, rs6675281, and rs821616. %26lt;br%26gt;Results: Region of interest analyses failed to reveal DISCI-associated morphological changes in the hippocampus, ACC, or striatum in MDD patients and healthy controls. Whole brain exploratory analyses identified a nominally significant cluster mapping to the border of the precentral and postcentral gyri associated with rs821616 in healthy controls only (p(uncorrected) %26lt; 0.001). %26lt;br%26gt;Limitations: We focused our analyses exclusively on three, but previously heavily studied, SNPs in DISC1. %26lt;br%26gt;Conclusions: Our findings suggest that morphological changes in the hippocampus, ACC, and/or striatum of MDD patients do not represent neurobiological mechanisms underlying the association between DISCI and MDD. However, we urge replication in independent samples of MDD cases.

• 出版日期2014-9