Emergence of a novel mutant PCV2b variant associated with clinical PCVAD in two vaccinated pig farms in the US concurrently infected with PPV2

作者：Opriessnig Tanja^*; Xiao Chao Ting; Gerber Priscilla F; Halbur Patrick G

来源：Veterinary Microbiology, 2013, 163(1-2): 177-183.

DOI：10.1016/j.vetmic.2012.12.019

• Porcine circovirus type 2 (PCV2)
• Vaccination
• Mutant PCV2
• Porcine parvovirus type 2 (PPV2)

Porcine circovirus (PCV) type 2b (PCV2b) emerged in North America in 2005-2006. During May of 2012, PCVAD occurred in 10-18-week-old pigs in two farms within a production system that routinely vaccinated against PCV2. Both farms received replacement gilts from the same multiplier. A mutant PCV2b strain not previously present in North America was identified. The strain was found to be 99.9% identical to a recently described mutant PCV2 isolate reported in China in 2010 and thought to be more virulent than classical PCV2a or PCV2b strains. It is possible that the current PCV2a-based commercial vaccines are not fully protective against this new strain. In addition, emerging porcine parvovirus type 2 (PPV2) was detected in 55% of the serum samples (73/132), perhaps implying that PPV2 could be a cofactor in cases of PCVAD.

• 出版日期2013-4-12