ADC Quantification of the Vertebral Bone Marrow Water Component: Removing the Confounding Effect of Residual Fat

作者：Dieckmeyer Michael^*; Ruschke Stefan; Eggers Holger; Kooijman Hendrik; Rummeny Ernst J; Kirschke Jan S; Baum Thomas; Karampinos Dimitrios C

来源：Magnetic Resonance in Medicine, 2017, 78(4): 1432-1441.

DOI：10.1002/mrm.26550

• bone marrow
• ADC quantification
• magnetic resonance spectroscopy (MRS)
• diffusion-weighted imaging (DWI)
• spine

PurposeTo remove the confounding effect of unsuppressed fat on the imaging-based apparent diffusion coefficient (ADC) of the vertebral bone marrow water component when using spectrally selective fat suppression and to compare and validate the proposed quantification strategy against diffusion-weighted magnetic resonance spectroscopy (DW-MRS).
MethodsTwelve subjects underwent diffusion-weighted imaging (DWI) and DW-MRS of the vertebral bone marrow. A theoretical model was developed to take into account and correct the effects of residual fat on ADC, incorporating additional measurements for proton density fat fraction (PDFF) and water T-2 (T-2w). Uncorrected and corrected DWI-based ADC was compared with DW-MRS-based ADC using the Bland-Altman method.
ResultsThere was a systematic bias equal to 0.1180.116x10(-3) mm(2)/s between DWI and DW-MRS when no correction was performed. Taking into account measured PDFF and constant T-2w reduced the bias to 0.006 +/- 0.128x10(-3) mm(2)/s. Using the proposed approach with both individually measured PDFF and T-2w reduced both the bias and the limits of agreement between DWI and DW-MRS (0.018 +/- 0.065x10(-3) mm(2)/s).
ConclusionBy taking into account the presence of residual fat in a modified signal model that incorporates additional individual measurements of PDFF and T-2w, good agreement of imaging-based ADC with MRS-based ADC can be achieved in vertebral bone marrow. Magn Reson Med 78:1432-1441, 2017.

• 出版日期2017-10