Association of Structural and Functional Measures With Contrast Sensitivity in Glaucoma

作者：Fatehi Nima; Nowroozizadeh Sara; Henry Sharon; Coleman Anne L; Caprioli Joseph; Nouri Mahdavi Kouros^*

来源：American Journal of Ophthalmology, 2017, 178: 129-139.

DOI：10.1016/j.ajo.2017.03.019

PURPOSE: To test the hypothesis that structural and functional measures predict contrast sensitivity (CS) outcomes in glaucomatous eyes.
DESIGN: Cross-sectional prospective study.
METHODS: One hundred five eyes of 65 patients who underwent macular spectral-domain optical coherence tomography imaging, 24-2 standard achromatic visual fields (VF), and CS measurement on the same day were enrolled. Association of CS at 4 spatial frequencies (3, 6, 12, and 18 cycles per degree, cpd) with structural and functional outcomes was explored with correlation and regression analyses.
RESULTS: The median (IQR) 24-2 visual field mean deviation was -7.6 (-11.1 to -3.0). Significant correlations were found between CS at 6 cpd and ganglion cell/inner plexiform layer thickness at inferotemporal and inferonasal macular sectors (rho = 0.222, P = .023 and rho = 0.209, P = .032, respectively). CS at 6 cpd demonstrated higher correlations with full macular thickness measurements, the strongest of which was with the central macular thickness in the superior 6 x 3-degree region (rho = 0.311, P = .001). Contrast sensitivity at 6 cpd also had the strongest correlation with mean deviation of the 4 central VF points (rho = -0.420; P < .001). There was a significant correlation between logMAR visual acuity and contrast sensitivity at 6, 12, and 18 cpd (rho = -0.306, rho = -0.348 and rho = -0.241, P < .013, respectively).
CONCLUSIONS: Structural and functional measures showed a fair relationship with contrast sensitivity. This association was most prominent between full-thickness macular measures or central VF parameters and CS at 6 cpd. Contrast sensitivity was not a reliable surrogate for glaucoma severity in this cross-sectional study.

• 出版日期2017-6