科研之友
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摘要
Rutin, a major flavonoid glycoside found in many higher plants, was exposed at 25kGy of gamma-ray and produced three new hydroxymethylated products 2-4 in the C-ring by gamma-irradiation. Structures of the new compounds, including absolute configurations, were elucidated based on spectroscopic interpretation (NMR, UV, [alpha](D), MS, and circular dichroism (CD)). The new unusual rutin derivatives 2 and 3 exhibited significantly enhanced inhibitory effects against alpha-glucosidase with IC50 values of 23.1 +/- 1.2 and 11.2 +/- 0.7 mu m, respectively, when compared to the parent rutin.
- 出版日期2017-7
