Microchimerism in Salivary Glands after Blood- and Marrow-Derived Stem Cell Transplantation

作者：Tran Simon D^*; Redman Robert S; Barrett A John; Pavletic Steven Z; Key Sharon; Liu Younan; Carpenter Ashley; Nguyen Hieu M; Sumita Yoshinori; Baum Bruce J; Pillemer Stanley R; Mezey Eva

来源：Biology of Blood and Marrow Transplantation, 2011, 17(3): 429-433.

DOI：10.1016/j.bbmt.2010.09.021

• Salivary glands
• Microchimerism
• Bone marrow stem cells
• Blood stem cells
• Transplantation

Blood- and marrow-derived stem cells (BMDSCs) provide disease-ameliorating effects for cardiovascular and autoimmune diseases. Microchimerism from donor BMDSCs has been reported in several recipient tissues. We hypothesized that this finding suggests a potential use of BMDSCs in the treatment of salivary dysfunctions. We investigated the presence of Y chromosome-positive cells in salivary gland biopsies of 5 females who had received a marrow or blood stem cell transplant from male donors. One to 16 years after transplantation, all recipients exhibited scattered Y chromosome-positive cells in the acini, ducts, and Stroma of their salivary glands (mean of 1.01%). Potentially, these cells can be markers of transplantation tolerance, contribute to neoplastic epithelial tissues, or engraft at sites of injury. In addition, transplantation of BMDSCs could be used for treatment of Sjogren's syndrome and salivary glands damaged by therapeutic irradiation for cancers of the head and neck.

• 出版日期2011-3