Analysis of bulk and virus-specific CD8+T cells reveals advanced differentiation of CD8+T cells in patients with common variable immunodeficiency

作者：Kuntz Martin; Goldacker Sigune; Blum Hubert E; Pircher Hanspeter; Stampf Susanne; Peter Hans Hartmut; Thimme Robert^*; Warnatz Klaus

来源：Clinical Immunology, 2011, 141(2): 177-186.

DOI：10.1016/j.clim.2011.07.006

• Common Variable Immunodeficiency
• Anti-viral CD8+T cell response
• Cytomegalovirus
• Epstein -Barr virus
• Influenza virus
• Lymphadenopathy

Common variable immunodeficiency (CVID) is a heterogeneous antibody deficiency syndrome with alterations in T cell regulation and function in a subgroup of patients. We assessed phenotype and function of bulk and virus-specific CD8+ T cells of a cohort of 34 HLA-A2+ CVID patients by pentamer technology and flow cytometry in relationship to their immunological and clinical phenotypes. Bulk CD8+ T cells displayed a shift toward a more antigen experienced and activated differentiation state. The advanced differentiation pattern was mainly found in a subgroup of CVID patients with lymphadenopathy and granulomatous disease. This effect existed independently of the patients CMV status even so CMV-associated immunosenescence was more evident in CVID patients than in CMV-positive immunocompetent controls. As the phenotype and function of virus-specific CD8+ T cells were normal in CVID the induction of antiviral immunity by prophylactic immunization appears to be a logical and desirable aim for this group of patients.

• 出版日期2011-11
• 单位河北医科大学