Absolute Configuration of (-)-Centratherin, a Sesquiterpenoid Lactone, Defined by Means of Chiroptical Spectroscopy

作者：Junior Fernando M S; Covington Cody L; de Albuquerque Ana Carolina F; Lobo Jonathas F R; Borges Ricardo M; de Amorim Mauro B; Polavarapu Prasad L

来源：Journal of Natural Products, 2015, 78(11): 2617-2623.

DOI：10.1021/acs.jnatprod.5b00546

(-)-Centratherin is a bioactive sesquiterpenoid lactone, whose absolute configuration (AC) was not established, but has been proposed based on those of germacrane precursors. To verify this proposal, the experimental electronic circular dichroism (ECD), electronic dissymmetry factor (EDF), optical rotatory dispersion (ORD), vibrational circular dichroism (VCD), and vibrational dissymmetry factor (VDF) spectra of (-)-centratherin have been analyzed with the corresponding density functional theoretical predictions. These analyses suggest the AC of naturally occurring (-)-centratherin to be (6R,7R,8S,10R,2'Z).

• 出版日期2015-11