Proliferation and Metabolism: It's as Easy as APC

作者：Tantin Dean; Rutter Jared^*

来源：Cell Metabolism, 2012, 15(4): 413-414.

DOI：10.1016/j.cmet.2012.03.012

Proliferating cells must generate both ATP and biosynthetic precursors for macromolecular synthesis. While proliferative signals have long been known to regulate metabolism, Garedew et al. now demonstrate that the proliferation apparatus itself, in the form of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C), directly controls mitochondrial biogenesis, morphology, and respiratory activity.

• 出版日期2012-4-4