ABC OF THE ABC TRANSPORTERS IN HUMAN ORGANISM

作者：Kowara Michal^*

来源：Postepy Biologii Komorki, 2012, 39(2): 143-158.

The ABC transporters are, after all, pumps responsible for elimination of xenobiotics (also chemotherapeutic agents) from the cell. Because of this reason the inhibitors of such transporters have been claimed to be important in the therapy. But it has turned out, that the ABC transporters are responsible not only for MDR (MultiDrug Resistance) phenomenon, but also for lipid transport (ABCA and ABCG except for ABCG2), regulation of intracellular processes like protein translation (ABCE and ABCF), peroxisome activity (ABCD), insulin secretion (ABCC8 and ABCC9) and regulation of mucus hydration in bronchi. Some diseases are caused by the defects of the ABC transporters, for instance cystic fibrosis (result of ABCC7 - CFTR mutation). In the current researches, new aspects of ABC transporters are being discovered. This article aims to present general aspects of ABC transporters like structure and evolution, as well as to go through the main function of the transporters.

• 出版日期2012