Gold(I) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro

作者：Serratice M; Bertrand B; Janssen E F J; Hemelt E; Zucca A; Cocco F; Cinellu M A^*; Casini A

来源：Medchemcomm, 2014, 5(9): 1418-1422.

DOI：10.1039/c4md00241e

A number of gold(I) complexes containing the proton pump inhibitor (PPI) lansoprazole and its reduced precursor 2-((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methylthio)-1H-benzo[d]imidazole have been synthesized and their biological effects have been evaluated in human cancer and nontumorigenic cells in vitro. The lansoprazole-based compounds appear to act through a V-H+-ATPase-mediated mechanism.

• 出版日期2014-9