Utility of serum periostin in combination with exhaled nitric oxide in the management of asthma

作者：Nagasaki Tadao; Matsumoto Hisako; Izuhara Kenji

来源：Allergology International, 2017, 66(3): 404-410.

DOI：10.1016/j.alit.2017.02.003

• Asthma
• Composite marker
• Nitric oxide
• Serum periostin
• Type-2/eosinophilic inflammation

Type-2/eosinophilic inflammation plays a pivotal role in asthma. The identification of severe type-2/eosinophilic asthma is important for improving the management of patients with asthma. Therefore, efforts to develop non-invasive biomarkers for type-2/eosinophilic airway inflammation have been made during this decade. Currently, fraction of exhaled nitric oxide (FeNO) and serum periostin levels are considered markers of type-2/eosinophilic inflammation in asthma. However, a single-marker approach has limited the ability to diagnose severe type-2/eosinophilic asthma accurately and predict disease outcomes precisely. The present article reviews the utility of FeNO and serum periostin levels in a single marker approach and in a multiple-marker approach in identifying patients with severe type-2/eosinophilic asthma. Furthermore, based on a sub-analysis of the Kinki Hokuriku Airway disease Conference (KiHAC), geno-endo-phenotypes of patients were stratified into four groups according to the FeNO and serum periostin levels.

• 出版日期2017-7