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摘要
By using Cinchona-derived chiral phosphines as catalytic ligands, enantioenriched cis-3a, 8a-hexahydropyrrolo[2,3-b] indoles (ent-HPIs), which are core scaffolds in a large array of biologically active natural products, can be convergently assembled under mild conditions through the silver(I)-catalyzed asymmetric domino reaction of readily available isocyanoacetates and 2-(2-aminophenyl) acrylates. Various functionalities can be tolerated in the reaction, affording enantioenriched HPIs in high overall yields and good enantioselectivities (up to 92% ees).
- 出版日期2016-3-17
- 单位杭州师范大学
