New Synthesis Approach for Hybrid Gd(III)-Loaded Nanocrystalline TiO2 as Potential Magnetic Resonance Imaging Contrast Agents

作者：Mendez Violaine; Daniele Stephane^*

来源：Journal of Nanoscience and Nanotechnology, 2011, 11(10): 9237-9243.

DOI：10.1166/jnn.2011.4287

• TiO2
• Alkoxide
• Nanoparticle
• Hybrid
• Gadolinium
• MRI T-1-Contrast Agents

A new aqueous "in situ and one pot" method to elaborate surface-functionalized Gd(III)-doped anatase TiO2 nanoparticles, starting from heterometallic/heteroleptic Gd-Ti alkoxides, is reported. Full characterization and thermal behaviour of the nanomaterials demonstrate that this molecular approach offers the convenience of working under soft temperature and pH conditions in order to allow fine tuning of the organic surface functionalization and gadolinium doping. In vitro phantom images exhibit potential MRI T-1-contrast agent properties.

• 出版日期2011-10