A Randomized, Masked Study of Weekly Erythropoietin Dosing in Preterm Infants

作者：Ohls Robin K^*; Roohi Mashid; Peceny Hannah M; Schrader Ronald; Bierer Ryann

来源：Journal of Pediatrics, 2012, 160(5): 790-U336.

DOI：10.1016/j.jpeds.2011.10.026

Objective To compare reticulocyte responses of once-per-week erythropoietin (EPO) dosing with 3-times-a-week dosing in preterm infants. %26lt;br%26gt;Study design Infants weighing %26lt;= 1500 g and %26gt;= 7 days of age were randomized to once-per-week EPO, 1200 U/kg/dose, or 3-times-a-week EPO, 400 U/kg/dose, subcutaneously for 4 weeks, along with iron and vitamin supplementation. Complete blood counts, absolute reticulocyte counts (ARCs), transfusions, phlebotomy losses, and adverse events were recorded. %26lt;br%26gt;Results Twenty preterm infants (962 +/- 55 g, 27.9 +/- 0.4 weeks, 17 +/- 3 days of age) were enrolled. Groups were similar at baseline. Infants in both groups had increased ARCs, which were similar between treatment groups at the start and end of 4 weeks. Hematocrit remained stable, and similar numbers of transfusions were administered. No adverse effects of either dosing schedule were noted. %26lt;br%26gt;Conclusions Preterm infants respond to weekly EPO by increasing ARCs and maintaining hematocrit. We speculate that once-per-week EPO dosing might be beneficial to preterm infants requiring increased erythropoiesis. (J Pediatr 2012;160:790-5).

• 出版日期2012-5