Nigral neurodegeneration triggered by striatal AdIL-1 administration can be exacerbated by systemic IL-1 expression

作者：Pott Godoy Maria Clara; Cintia Ferrari Carina; Juan Pitossi Fernando

来源：Journal of Neuroimmunology, 2010, 222(1-2): 29-39.

DOI：10.1016/j.jneuroim.2010.02.018

• Cytokine
• Dexamethasone
• Systemic inflammation
• Motor behaviour

Neuroinflammation has been proposed as an important component of Parkinson's Disease (PD) aetiology and/or progression. However, the inflammatory components and the mechanisms underlying their effects are only partially known. By injecting an adenovirus expressing IL-1 in the striatum, we provoked progressive neurodegeneration of dopaminergic cells in the substantia nigra, motor symptoms and microglial activation. All these effects were attenuated by an anti-inflammatory treatment. Interestingly, peripheral inflammatory stimuli exacerbated IL-1 beta induced neurodegeneration and the central inflammatory reaction.
These data provide evidence that central, chronic IL-1 beta expression can trigger and systemic IL-1 beta exacerbate nigral neurodegeneration and highlight the functional relevance of this cytokine in PD.

• 出版日期2010-5