Apparent diffusion coefficient measurements in diffusion-weighted magnetic resonance imaging of the anterior mediastinum: inter-observer reproducibility of five different methods of region-of-interest positioning

作者：Priola Adriano Massimiliano; Priola Sandro Massimo; Parlatano Daniela; Gned Dario; Giraudo Maria Teresa; Giardino Roberto; Ferrero Bruno; Ardissone Francesco; Veltri Andrea

来源：European Radiology, 2017, 27(4): 1386-1394.

DOI：10.1007/s00330-016-4527-8

• Diffusion-weighted magnetic resonance imaging
• Apparent diffusion coefficient
• Anterior mediastinum
• Inter-observer variability
• Region of interest

To investigate inter-reader reproducibility of five different region-of-interest (ROI) protocols for apparent diffusion coefficient (ADC) measurements in the anterior mediastinum.
In eighty-one subjects, on ADC mapping, two readers measured the ADC using five methods of ROI positioning that encompassed the entire tissue (whole tissue volume [WTV], three slices observer-defined [TSOD], single-slice [SS]) or the more restricted areas (one small round ROI [OSR]), multiple small round ROI [MSR]). Inter-observer variability was assessed with interclass correlation coefficient (ICC), coefficient of variation (CoV), and Bland-Altman analysis. Nonparametric tests were performed to compare the ADC between ROI methods. The measurement time was recorded and compared between ROI methods.
All methods showed excellent inter-reader agreement with best and worst reproducibility in WTV and OSR, respectively (ICC, 0.937/0.874; CoV, 7.3 %/16.8 %; limits of agreement, +/- 0.44/+/- 0.77 x 10(-3) mm(2)/s). ADC values of OSR and MSR were significantly lower compared to the other methods in both readers (p < 0.001). The SS and OSR methods required less measurement time (14 +/- 2 s) compared to the others (p < 0.0001), while the WTV method required the longest measurement time (90 +/- 56 and 77 +/- 49 s for each reader) (p < 0.0001).
All methods demonstrate excellent inter-observer reproducibility with the best agreement in WTV, although it requires the longest measurement time.
aEuro cent All ROI protocols show excellent inter-observer reproducibility.
aEuro cent WTV measurements provide the most reproducible ADC values.
aEuro cent ROI size and positioning influence ADC measurements in the anterior mediastinum.
aEuro cent ADC values of OSR and MSR are significantly lower than other methods.
aEuro cent OSR and WTV methods require the shortest and longest measurement time, respectively.

• 出版日期2017-4