Assessment of memory/attention impairment in children with primary nocturnal enuresis: A voxel-based morphometry study

作者：Yu, Bing; Kong, Fanxing; Peng, Miao; Ma, Hongwei; Liu, Na; Guo, Qiyong^*

来源：European Journal of Radiology, 2012, 81(12): 4119-4122.

DOI：10.1016/j.ejrad.2012.01.006

• Enuresis
• Children
• Brain mapping
• Magnetic resonance imaging

Aim: Assessment of memory/attention impairment and related exploration of the gray matter differential MR density variations between children with and without primary nocturnal enuresis (PNE) using voxel-based morphometry (VBM) methodology is the aim of the present study.
Methods: A total of 75 right-handed PNE children (M/F = 39:36, average age 10.4 +/- 1.3 years) and 72 age-matched, right-handed, healthy controls (M/F = 40:32, 10.0 +/- 1.2 years) were recruited for the study. First, intelligence tests were performed using the China-Wechsler Intelligence Scale for Children (C-WISC) in both PNE and control children. The full intelligence quotient (FIQ), verbal IQ (VIQ), performance IQ (PIQ), and memory/caution (M/C) factor were measured. Voxel-based morphometry (VBM) was performed using high resolution 3 Tesla T1-weighted MR images, processed using VBM5 in the PNE and control children. Student's t-test or Mann-Whitney U test were performed to analyze the difference in the gray matter density (GMD) between the PNE and control children.
Results: The FIQ, VIQ, and PIQ in the PNE group were within the normal range and did not significantly differ from the control group, though the M/C factor was statistically lower in the PNE group. Compared with normal controls, PNE children exhibited lower GMD in the right dorsolateral prefrontal cortex (DLPFC) and the left cerebellum (P < 0.001).
Conclusion: Impairment in memory/attention was detected in PNE children, and the structural abnormalities of the right DLPFC and left cerebellum are likely to be implicated in these deficits.

• 出版日期2012-12
• 单位辽宁省人民医院; 中国医科大学