Virulence and Antibiotic Resistance of Pseudomonas aeruginosa Isolated from Patients with Urinary Tract Infections in Southern Poland

作者：Pobiega Monika^*; Wojkowska Mach Jadwiga; Maciag Joanna; Chmielarczyk Agnieszka; Romaniszyn Dorota; Pomorska Wesolowska Monika; Ziolkowski Grzegorz; Heczko Piotr B; Bulanda Malgorzata

来源：Chemotherapy, 2015, 60(4): 253-260.

DOI：10.1159/000376569

• Antimicrobial susceptibilities
• Multidrug resistance
• Polymicrobial infections
• Pseudomonas aeruginosa
• Urinary tract infections

Background: The aim of this study was to analyze the resistance and virulence of Pseudomonas aeruginosa strains causing urinary tract infections in in-and outpatients in Southern Poland. Methods: The study included 83 inpatients and 66 outpatients; 36.9% were female. Results: Monomicrobial infections accounted for 74.5%; polymicrobial infections occurred more frequently among inpatients (odds ratio, OR = 4.32, p = 0.0008). exoS and lasB were detected in 90 and 74% of isolates, respectively. aprA was present in 66%, pilB in 5% and pilA in 23% of isolates. Isolates from adults were more frequently resistant to fluoroquinolones (OR = 0.37, p = 0.029). Twenty-nine isolates were classified as multidrug resistant and 12 as extremely drug resistant, which occurred less frequently in patients <17 years (OR = 0.18, p = 0.024). Nine metallo-beta-lactamase-positive isolates were identified. bla(SHV) was present in 10, bla(TEM) in 6, bla(OXA-10) in 3 and bla(VIM-2) in 3 isolates. Conclusion: Antibiotic selection should be based on the knowledge of local antimicrobial susceptibilities to maximize the benefit for patients and minimize the risk of drug resistance.

• 出版日期2015