Diversity-Oriented Stereoselective Synthesis beta,gamma-Disubstituted tert-Homoallylic Alcohols

作者:Takeda Takeshi*; Amarume Sota; Sekioka Ippei; Tsubouchi Akira
来源:Organic Letters, 2015, 17(5): 1150-1153.
DOI:10.1021/acs.orglett.5b00084

摘要

The successive treatment of beta-(trimethylsilyl)allyl phenyl sulfides with titanocene(II)-1-butene complex and ketones produced tertiary gamma-(trimethylsilyl)homoallylic alcohols with good anti-selectivity, which reacted with a variety of organic halides in the presence of copper(I) tert-butoxide to afford the cross-coupling products, gamma-substituted homoallylic alcohols.

  • 出版日期2015-3-6