A study of the chitosan coating method on polyglycolic acid and polylactic acid embedding monofilaments

作者：Fu, Shao-ju; Zhang, Pei-hua^*

来源：Textile Research Journal, 2019, 89(3): 270-280.

DOI：10.1177/0040517517743686

• acupoint catgut embedding therapy
• polyglycolic acid
• polylactic acid
• chitosan
• self-swelling behavior

With the development of applying acupoint catgut embedding therapy to the treatment of juvenile pseudomyopia, embedding materials are expected to be the perfect for choice by taking advantage of the lasting effect and minimal invasiveness. This work adopted polyglycolic acid (PGA) and polylactic acid (PLA) monofilaments to produce four types of chitosan coated monofilaments with excellent swelling behaviors. For achieving better coating weight gains, a one-dipping-one-rolling coating system was developed. The results showed that both the PGA and PLA monofilaments' swelling behaviors were greatly improved, CS-PGA2 (98.17 +/- 3.15%) presented a great difference from CS-PLA1 (47.56 +/- 6.15%) and CS-PLA2 (63.31 +/- 3.26%), respectively, while CS-PGA1 (87.36 +/- 5.16%) had a similar expansion rate to that of CS-PGA2. The resist deformation ability of the monofilament was strengthened and the crystalline zones of PGA and PLA monofilaments were slightly decreased after a chitosan coating process. The CS-PGA group and PGA group were found to degrade completely in 56 days and 70 days, respectively, while the PLA group changed little in the experimental process, offering a new insight into controlled degradation research. In conclusion, all coated monofilaments show potential in acting as embedding materials with good swelling behaviors, and the CS-PGA group is proved to have a higher prospect for clinical applications.

• 出版日期2019-2
• 单位东华大学