Fast Determination of Ciprofloxacin by Batch Injection Analysis with Amperometric Detection and Capillary Electrophoresis with Capacitively Coupled Contactless Conductivity Detection

作者：Montes Rodrigo H O; Marra Mariana C; Rodrigues Monike M; Richter Eduardo M; Munoz Rodrigo A A^*

来源：Electroanalysis, 2014, 26(2): 432-438.

DOI：10.1002/elan.201300474

• Amperometry
• Antibiotic
• Boron-doped diamond electrode
• Pharmaceuticals

We report fast, precise, selective, and sensitive electroanalytical methods for the determination of ciprofloxacin in milk and pharmaceutical samples by batch-injection analysis with amperometric detection (BIA-AMP) and by capillary electrophoresis with capacitively-coupled contactless conductivity detection (CE-(CD)-D-4). Both methods required simple sample preparation protocols before analysis (milk samples were just diluted and tablets powdered and dissolved in electrolyte/water). The analytical features of BIA-AMP and CE-(CD)-D-4 methods include, respectively, low relative standard deviation values for repetitive measurements (2.8% and 1.7%, n=10), low detection limits (0.3 and 5.0 mu molL(-1)), elevated analytical frequency (80 and 120h(-1)) and satisfactory accuracy (based on comparative determinations by HPLC and recovery values for spiked samples).

• 出版日期2014-2