A novel turn-on Schiff-base fluorescent sensor for aluminum(III) ions in living cells

作者：Tian, Jianfei; Yan, Xiaxia; Yang, Hui; Tian, Fuli^*

来源：RSC Advances, 2015, 5(129): 107012-107019.

DOI：10.1039/c5ra17557g

• SELECTIVE DETECTION
• METAL-IONS
• ALZHEIMERS-DISEASE
• CHEMOSENSOR
• AL3+
• AL(III)
• PROBE
• COUMARIN
• ZN(II)
• ZN2+

(E)-4-Methoxy-N-((8-methylquionline-2yl)methylene)aniline (L) was successfully synthesized and characterized. The complexation behavior of L with different metal ions was studied using UV-Vis absorption spectroscopy and fluorescence spectroscopy. Results showed that the sensor (L) exhibited a 38-fold enhancement in fluorescence at 517 nm after adding 10 equiv. of Al3+ ions. Such fluorescent responses could be detected by the naked eye under a UV-lamp at 365 nm. The complex solution (L-Al3+) showed reversibility with EDTA and the complex was a 1 : 1 ratio according to Job's plot and electrospray ionization mass spectroscopy (ESI-MS). A photoinduced electron transfer (PET) mechanism was considered to be operational for fluorescence enhancement. The detection limit of Al3+ was calculated to be 1.2 x 10(-7) M, a satisfying level to detect Al3+ in the micromolar scale. Importantly, the chemosensor L could be used to detect and quantify Al3+ in living cells. Therefore, this sensor has the ability to be a practical system for monitoring Al3+ concentrations in biological systems.

• 出版日期2015
• 单位内蒙古大学