A facile, one-pot procedure for the formation of benzimidazoles from esters using DABAL-Me-3, an air stable source of AlMe3

作者：Pinder Joanne L^*; Davis Rebecca E; Charrier Jean Damien

来源：Tetrahedron Letters, 2014, 55(35): 4853-4855.

DOI：10.1016/j.tetlet.2014.06.026

• Benzimidizole
• DABAL-Me-3
• Cyclodehydration
• Heterocycles

A convenient, single-step, efficient synthesis of benzimidazoles from esters and diamines is reported. The methodology uses an air stable form of trimethylaluminum referred to as DABAL-Me-3 and is compatible with a wide range of functional groups, including acid-sensitive protecting groups.

• 出版日期2014-8-27