Novel Tetraindoles and Unexpected Cycloalkane Indoles from the Reaction of Indoles and Aliphatic Dialdehydes

作者:El Sayed Mardia Telep; Mahmoud Kazem Ahmed; Heinemann Frank W; Hilgeroth Andreas*
来源:Journal of Heterocyclic Chemistry, 2017, 54(1): 714-719.
DOI:10.1002/jhet.2542

摘要

The reaction of indoles with dialdehydes was studied for the first time. Mild reaction conditions using glacial acetic acid led to two novel kinds of reaction products: one designated as alkyl chain-connected tetraindoles and the other one as bis( indolyl)-substituted cycloalkane indoles. The suggested reaction pathways are discussed. The indole substituents of the cycloalkane indoles were either trans or cis orientated depending from the alkyl chain length.

  • 出版日期2017-1