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摘要
Cyclopropanation was performed using the Furukawa procedure with CH2I2/Et2Zn and alpha,beta-unsaturated ketones. The reaction was performed in the presence of a copper salt. The reactivity was highly dependent on the substrate structure, and cyclopropanated products were obtained in better yields than those achieved using the original Simmons-Smith conditions with a Zn-Cu couple in some cases. Stereospecificity was observed in a certain case; however, the synthesis of an asymmetric version with a chiral ligand was not successful.
- 出版日期2014-5-5
