Highly enantioselective copper(I)-catalyzed conjugate addition of 1,3-diynes to alpha,beta-unsaturated trifluoromethyl ketones

作者：Sanz Marco Amparo; Blay Gonzalo^*; Carmen Munoz M; Pedro Jose R

来源：Chemical Communications, 2015, 51(43): 8958-8961.

DOI：10.1039/c5cc01676b

The conjugate diynylation of alpha,beta-unsaturated trifluoromethyl ketones is carried out in the presence of a low catalytic load (2.5 mol%) of a copper(I)-MeOBIPHEP complex, triethylamine and a terminal 1,3-diyne. Pre-metalation of the terminal 1,3-diyne with stoichiometric or higher amounts of dialkylzinc reagent is not required. The corresponding internal diynes bearing a propargylic stereogenic center are obtained with good yields and excellent enantioselectivities.

• 出版日期2015