Nitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp.

作者：Rasamison Vincent E; Rakotondraibe L Harinantenaina; Slebodnick Carla; Brodie Peggy J; Ratsimbason Michel; TenDyke Karen; Shen Yongchun; Randrianjanaka Lucien M; Kingston David G I^*

来源：Organic Letters, 2014, 16(10): 2626-2629.

DOI：10.1021/ol500775r

The new triterpene turranoic acid (1) and the new N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1-3 showed weak to moderate in vitro antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum strain FCM29. Compound 1 also displayed weak cytotoxic activity against the nonsmall lung cancer cell line H522-T1 with an IC50 value of 16.4 mu M.

• 出版日期2014-5-16
• 单位Virginia Tech; 美国弗吉尼亚理工大学(Virginia Tech)